Stem cells for the treatment of urinary incontinence. Academic Article uri icon

Overview

abstract

  • Stress urinary incontinence (SUI) is highly prevalent. As of now, there is no minimally invasive long-term treatment available. Adult stem cells are nonimmunogenic and have the ability to self-renew and to differentiate into multiple cell types. Over the past decade, in vivo studies have described periurethral injections of adult-derived stem cells for the treatment of SUI. The ultimate goal has been to achieve a permanent cure for SUI by restoration of the intrinsic and extrinsic urethral sphincter and the surrounding connective tissue, including peripheral nerves and blood vessels. For this purpose, future studies need to focus on delivery systems, cell survival, and functional improvement of the urethral closure mechanism, including improvement of innervation and vascularization.

publication date

  • February 1, 2011

Research

keywords

  • Stem Cell Transplantation
  • Urinary Incontinence, Stress

Identity

PubMed Central ID

  • PMC3021255

Scopus Document Identifier

  • 79551512855

Digital Object Identifier (DOI)

  • 10.1111/j.1442-2042.2009.02429.x

PubMed ID

  • 21113694

Additional Document Info

volume

  • 12

issue

  • 1