Radiosynthesis of [(18)F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins.
Academic Article
Overview
abstract
To probe the in vivo role of stress response factors in normal physiology and in solid tumors we have designed a stable (18)F-labeled molecular imaging agent based on a ligand for heat shock protein 70 (HSP70). We describe the synthesis of [(18)F] fluorodeoxymethylspergualin ([(18)F]MeDSG) as a new radiopharmaceutical probe using a prosthetic group, [(18)F]SFB, for efficient and rapid radiolabeling. Ongoing molecular imaging studies are under way to detect HSP70 expression in tumors by positron emission tomography.
