Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion. uri icon

Overview

abstract

  • Acute bilineal leukemias are rare and are commonly associated with t(9;22) and MLL abnormalities. Herein, we report a pediatric case of bilineal T/myeloid acute leukemia associated with del (9q)(q13q22) and TLX3/BCL11B fusion due to the cryptic t(5;14)(q35;32). FISH studies confirmed the TLX3/BCL11B fusion in both the myeloid and lymphoid blasts, while the 9q deletion was restricted to the lymphoid component. Optimal therapy for such patients remains controversial and it is not clear if they should be treated with ALL or AML-based chemotherapeutic regimens. Our patient has been in extended remission following ALL-based chemotherapy and a matched unrelated cord blood transplant. Inc.

publication date

  • November 11, 2010

Research

keywords

  • Chromosomes, Human, Pair 9
  • Homeodomain Proteins
  • Leukemia, Biphenotypic, Acute
  • Leukemia, Myeloid, Acute
  • Leukemia, T-Cell
  • Oncogene Proteins, Fusion
  • Repressor Proteins
  • Tumor Suppressor Proteins

Identity

Scopus Document Identifier

  • 78651102843

Digital Object Identifier (DOI)

  • 10.1002/pbc.22850

PubMed ID

  • 21225930

Additional Document Info

volume

  • 56

issue

  • 3