Brain networks in Huntington disease. Review uri icon

Overview

abstract

  • Recent studies have focused on understanding the neural mechanisms underlying the emergence of clinical signs and symptoms in early stage Huntington disease (HD). Although cell-based assays have focused on cell autonomous effects of mutant huntingtin, animal HD models have revealed alterations in the function of neuronal networks, particularly those linking the cerebral cortex and striatum. These findings are complemented by metabolic imaging studies of disease progression in premanifest subjects. Quantifying metabolic progression at the systems level may identify network biomarkers to aid in the objective assessment of new disease-modifying therapies and identify new regions that merit mechanistic study in HD models.

publication date

  • February 1, 2011

Research

keywords

  • Huntington Disease
  • Nerve Net

Identity

PubMed Central ID

  • PMC3026742

Scopus Document Identifier

  • 79551519277

Digital Object Identifier (DOI)

  • 10.1111/j.1471-4159.2005.03515.x

PubMed ID

  • 21285521

Additional Document Info

volume

  • 121

issue

  • 2