The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation. uri icon

Overview

abstract

  • OBJECTIVE: To report a case of successful paternity from a male homozygous for 5α-reductase-2 deficiency. DESIGN: Case report. SETTING: Academic center, division of reproductive endocrinology. PATIENT(S): A 45-year-old Dominican man and his 32-year-old wife. INTERVENTION(S): In vitro fertilization and intracytoplasmic sperm injection. MAIN OUTCOME MEASURE(S): Pregnancy. RESULT(S): Viable twin gestation. CONCLUSION(S): Men homozygous for 5α-reductase-2 deficiency can achieve biologic paternity through in vitro fertilization with intracytoplasmic sperm injection despite severely abnormal semen parameters.

publication date

  • February 19, 2011

Research

keywords

  • Cholestenone 5 alpha-Reductase
  • Fertilization in Vitro
  • Infertility, Male
  • Mutation

Identity

Scopus Document Identifier

  • 79954991707

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2011.01.121

PubMed ID

  • 21334614

Additional Document Info

volume

  • 95

issue

  • 6