Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells. uri icon

Overview

abstract

  • We have characterized a child with a severe combined immunodeficiency disease syndrome with increased numbers, but a normal distribution, of CD3+ T cells. This patient's immunological defect appears to be attributable to a selective deficiency in T cell production of IL-2, which may reflect a subtle abnormality in the IL-2 gene locus or a defect in a regulatory factor necessary for IL-2 transcription. The increased numbers of phenotypically normal T cells in this patient suggest that alternative pathways of T cell development exist in man or that IL-2 production intra- and extrathymically is controlled via distinct regulatory mechanisms.

publication date

  • May 1, 1990

Research

keywords

  • Immunologic Deficiency Syndromes
  • Interleukin-2
  • T-Lymphocytes

Identity

PubMed Central ID

  • PMC2187905

Scopus Document Identifier

  • 0025289836

Digital Object Identifier (DOI)

  • 10.1084/jem.171.5.1697

PubMed ID

  • 2139699

Additional Document Info

volume

  • 171

issue

  • 5