Interrelationship between atrial natriuretic factor concentrations and acute volume expansion in pregnant and nonpregnant women. Academic Article uri icon

Overview

abstract

  • The secretion of atrial natriuretic factor by human atrial myocytes is stimulated by increased intraatrial pressure or atrial distention. To determine whether acute intravascular volume expansion affects atrial natriuretic factor concentrations during pregnancy, circulating atrial natriuretic factor levels were measured in pregnant women at term (before elective cesarean section) and nonpregnant control subjects before and during intravenous infusion of lactated Ringer's solution (approximately 30 ml/kg). Venous plasma concentrations of alpha-human atrial natriuretic factor were determined by a specific radioimmunoassay. A significant increase in alpha-human atrial natriuretic factor levels in nonpregnant subjects was seen. Pregnant women did not show a significant response to a similar stimulus. Finally, basal alpha-human atrial natriuretic factor levels in pregnant and nonpregnant women were not different. Volume expansion (long-term or short-term) in normal human pregnancy may not be sensed by atrial volume sensors, possibly because it is accommodated by an enlarged maternal vascular compartment.

publication date

  • July 1, 1990

Research

keywords

  • Atrial Natriuretic Factor
  • Plasma Substitutes
  • Pregnancy

Identity

Scopus Document Identifier

  • 0025082787

Digital Object Identifier (DOI)

  • 10.1016/s0002-9378(11)90664-4

PubMed ID

  • 2142856

Additional Document Info

volume

  • 163

issue

  • 1 Pt 1