Anaplastic lymphoma kinase in human cancer. Review uri icon

Overview

abstract

  • The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.

publication date

  • July 4, 2011

Research

keywords

  • Lymphoma
  • Receptor Protein-Tyrosine Kinases

Identity

Scopus Document Identifier

  • 79961088497

Digital Object Identifier (DOI)

  • 10.1530/JME-11-0004

PubMed ID

  • 21502284

Additional Document Info

volume

  • 47

issue

  • 1