Are age cutoffs still used to identify candidates for invasive testing for chromosomal abnormalities? Academic Article uri icon

Overview

abstract

  • OBJECTIVE: Our objective was to determine whether women > or = age 35 are more likely to undergo invasive testing after risk adjustment as compared with younger women at similar adjusted risk. STUDY DESIGN: Results of first-trimester combined aneuploidy risk assessment of singleton pregnancies from 2007-2008 were reviewed. For each level of adjusted risk, the rate of invasive testing (CVS or amniocentesis) was compared for those < age 35 and those > or = age 35. Spearman correlation, Fisher's exact test, and chi2 for trend were used for statistical comparison. RESULTS: For all categories except adjusted risk of 1 in < or = 250, women > or = age 35 were significantly more likely to undergo invasive testing as compared with younger women of similar risk. In women > or = age 35 with low adjusted risk, we observed a trend towards lower rates of invasive testing over time. CONCLUSION: The higher rate of invasive testing in those > or = 35 indicates that women are still being categorized based on age, though our data suggest this may be decreasing.

publication date

  • January 1, 2011

Research

keywords

  • Aneuploidy
  • Maternal Age
  • Prenatal Diagnosis

Identity

Scopus Document Identifier

  • 84877842317

PubMed ID

  • 21542527

Additional Document Info

volume

  • 56

issue

  • 3-4