Pancreas transplantation considering the spectrum of body mass indices.
Academic Article
Overview
abstract
BACKGROUND: In kidney, liver, heart, and lung transplantation, extremes of body mass index (BMI) have been reported to influence post-operative outcomes and even survival. Given the limited data in pancreas transplantation, we sought to elucidate the influence of BMI on outcomes. METHODS: We reviewed 139 consecutive pancreas transplants performed at our institution and divided them into four categories based on BMI: underweight (≤18.5kg/m(2)), normal (18.6-24.9kg/m(2)), overweight (25-29.9kg/m(2)), and obese (≥30kg/m(2)). Parameters analyzed included post-operative complications, early graft loss, one-yr acute rejection rate (AR), non-surgical infections, and survival. RESULTS: Demographic data were similar between the groups. Compared with normal, only obese patients trended toward more post-operative complications (p=0.06). Underweight and obese patients had significantly more post-operative infectious complications than normal (p=0.0005 and p=0.03, respectively). Obese patients had more complications requiring percutaneous drainage compared with normal (p=0.03). Overweight and obese patients had significantly more complications requiring re-laparotomy (p=0.03 and p=0.048, respectively). Early graft loss, AR, non-surgical infections, and patient and graft survival rates were not different between normal and underweight, overweight, or obese patients (p>0.05). CONCLUSIONS: Extremes of BMI were associated with increased morbidity. Donors and recipients should be carefully selected to maximize potential for successful outcomes.
