FoxO family members in cancer. Review uri icon

Overview

abstract

  • The PI3K-Akt-FoxO signaling pathway plays a central role in diverse physiological processes including cellular energy storage, growth, and survival, among others. As an important effector of this pathway, FoxO is involved in versatile activities that protect organisms from stress and aging. Recent studies on mammalian FoxO have established a direct role for this transcription factor family in cellular proliferation, oxidative stress response, and tumorigenesis. The review will focus on the recent developments pertaining to the function of FoxO as well as discuss the various contexts in which FoxO exerts distinct biological activity such as drug resistance and autophagy in cancer pathogenesis and therapy.

publication date

  • August 15, 2011

Research

keywords

  • Forkhead Transcription Factors
  • Neoplasms
  • Signal Transduction
  • Transcription Factors

Identity

Scopus Document Identifier

  • 84860420398

Digital Object Identifier (DOI)

  • 10.4161/cbt.12.4.15954

PubMed ID

  • 21613825

Additional Document Info

volume

  • 12

issue

  • 4