Hiding the road signs that lead to tumor immunity. Review uri icon

Overview

abstract

  • Tumors exploit many strategies to evade T cell-mediated destruction. For example, tumors can prevent T cell infiltration by modifying gene expression in the endothelial cells and pericytes that form their vasculature. New work showing that the T cell-attracting chemokine CCL2 can be posttranslationally modified in the tumor microenvironment adds another mechanism to the already formidable arsenal of immunoevasion tactics used by solid tumors.

publication date

  • September 26, 2011

Research

keywords

  • Neoplasms
  • Tumor Microenvironment

Identity

PubMed Central ID

  • PMC3182053

Scopus Document Identifier

  • 80555144960

Digital Object Identifier (DOI)

  • 10.1126/science.1203486

PubMed ID

  • 21948803

Additional Document Info

volume

  • 208

issue

  • 10