LED-Based Optical Device for Chronic In Vivo Cerebral Blood Volume Measurement. Academic Article uri icon

Overview

abstract

  • We demonstrate a reflectivity-based cerebral blood volume sensor comprised of surface-mount light-emitting diodes on a flexible substrate with integrated photodetectors in a form factor suitable for direct brain contact and chronic implantation. This reflectivity monitor is able to measure blood flow through the change of the surface reflectivity and, through this mechanism, detect the cerebral-blood-volume changes associated with epileptic seizures with a signal-to-noise (SNR) response of 42 dB. The device is tested in an in vivo model confirming its compatibility and sensitivity. The data taken demonstrate that placing the sensor into direct brain contact improves the SNR by more than four orders of magnitude over current noncontact technologies.

publication date

  • January 1, 2010

Identity

PubMed Central ID

  • PMC3203522

Scopus Document Identifier

  • 73349091812

Digital Object Identifier (DOI)

  • 10.1109/TED.2009.2033652

PubMed ID

  • 22039308

Additional Document Info

volume

  • 57

issue

  • 1