Hematopoietic stem cell engineering at a crossroads. Review uri icon

Overview

abstract

  • The genetic engineering of hematopoietic stem cells is the basis for potentially treating a large array of hereditary and acquired diseases, and stands as the paradigm for stem cell engineering in general. Recent clinical reports support the formidable promise of this approach but also highlight the limitations of the technologies used to date, which have on occasion resulted in clonal expansion, myelodysplasia, or leukemogenesis. New research directions, predicated on improved vector designs, targeted gene delivery or the therapeutic use of pluripotent stem cells, herald the advent of safer and more effective hematopoietic stem cell therapies that may transform medical practice. In this review, we place these recent advances in perspective, emphasizing the solutions emerging from a wave of new technologies and highlighting the challenges that lie ahead.

publication date

  • November 17, 2011

Research

keywords

  • Cell Engineering
  • Hematopoietic Stem Cells

Identity

PubMed Central ID

  • PMC3277348

Scopus Document Identifier

  • 84856622896

Digital Object Identifier (DOI)

  • 10.1038/nrc3179

PubMed ID

  • 22096239

Additional Document Info

volume

  • 119

issue

  • 5