Environmental toxicology of testicular cancer. Review uri icon

Overview

abstract

  • OBJECTIVE: Testicular cancer incidence appears to be increasing. In many regions, industrialization results in the production of potentially carcinogenic environmental toxins. We review the available data linking environmental toxins to testicular germ cell tumors (TGCT). METHODS: A PubMed review of the English literature was performed to identify studies evaluating the relationship between environmental toxins and TGCT. RESULTS: Many environmental toxins have been implicated in the development of TGCT, including organochlorines, polychlorinated biphenyls, polyvinyl chlorides, phthalates, marijuana, and tobacco. Variable levels of evidence exist and significant study design limitations preclude a definitive etiologic role for individual environmental toxins. CONCLUSION: Environmental toxins may play an important but undetermined role in the development of TGCT. Further work is needed to evaluate specific toxins and TGCT carcinogenesis.

publication date

  • January 1, 2012

Research

keywords

  • Environmental Exposure
  • Testicular Neoplasms

Identity

Scopus Document Identifier

  • 84857623416

Digital Object Identifier (DOI)

  • 10.1016/j.urolonc.2011.09.009

PubMed ID

  • 22385991

Additional Document Info

volume

  • 30

issue

  • 2