Effects of cell membrane disruption on the relaxation rates of blood and clot with various methemoglobin concentrations. Academic Article uri icon

Overview

abstract

  • The magnetic resonance imaging (MRI) characteristics of hemorrhage and clotted blood change with age. The effects of methemoglobin and cell membrane lysis, factors which in part may underlie this evolution of imaging characteristics, were studied using clotted and heparinized dog blood at various methemoglobin concentrations. Cell lysis did not alter the longitudinal relaxation rate (1/T1) in clotted or unclotted samples. Membrane lysis altered significantly the transverse relaxation rate (1/T2) in both clotted and unclotted samples. Lysed samples of oxygenated blood at 0% methemoglobin had significantly higher T2 values than intact samples. At 0% methemoglobin, clotted samples had slightly but significantly shorter relaxation times than unclotted samples. Within the samples studied, large changes in the state of oxygenation and methemoglobin content were observed in less than 24 h. Such changes necessitate frequent monitoring of these parameters if serial studies are to be done.

publication date

  • November 1, 1990

Research

keywords

  • Blood Coagulation
  • Blood Physiological Phenomena
  • Erythrocyte Membrane
  • Magnetic Resonance Imaging
  • Methemoglobin

Identity

Scopus Document Identifier

  • 0025048022

Digital Object Identifier (DOI)

  • 10.1097/00004424-199011000-00015

PubMed ID

  • 2254058

Additional Document Info

volume

  • 25

issue

  • 11