Blockade of morphine analgesia by both pertussis and cholera toxins in the periaqueductal gray and locus coeruleus. Academic Article uri icon

Overview

abstract

  • Rats demonstrating analgesia following microinjection of morphine into the periaqueductal gray (PAG) or locus coeruleus (LC) were injected with either pertussis toxin, cholera toxin or saline into the same brain region. Both pertussis and cholera toxin blocked the analgesic effect of morphine at both injection sites for up to 7 days after toxin treatment. These results indicate that morphine analgesia is a complex response involving systems dependent upon Gs as well as Gi or Go proteins.

publication date

  • October 8, 1990

Research

keywords

  • Analgesia
  • Cholera Toxin
  • Locus Coeruleus
  • Morphine
  • Periaqueductal Gray
  • Pertussis Toxin
  • Virulence Factors, Bordetella

Identity

Scopus Document Identifier

  • 0025110028

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(90)90845-3

PubMed ID

  • 2282501

Additional Document Info

volume

  • 529

issue

  • 1-2