Two cases of CD30+, anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma with oral manifestations. Academic Article uri icon

Overview

abstract

  • Anaplastic large cell lymphoma (ALCL), a subgroup of T-cell non-Hodgkin's lymphoma, is an uncommon tumor exhibiting CD30 positivity and a characteristic immunophenotypic profile. Histologically, ALCL is characterized by the proliferation of large, anaplastic lymphoid cells with eccentric horseshoe- or kidney-shaped nuclei and one or more prominent nucleoli. Rare cases have been cited in the literature of ALCL presenting primarily in the oral cavity. The purpose of this article was to present 2 instructive cases of CD30+, anaplastic lymphoma kinase-negative ALCL with oral and systemic involvement.

publication date

  • August 31, 2012

Research

keywords

  • Lymphoma, Large-Cell, Anaplastic
  • Mouth Neoplasms
  • Tongue Neoplasms

Identity

Scopus Document Identifier

  • 84872294194

Digital Object Identifier (DOI)

  • 10.1016/j.oooo.2012.04.010

PubMed ID

  • 22940020

Additional Document Info

volume

  • 115

issue

  • 2