Patterns of malformation in children with congenital diaphragmatic defects. Academic Article uri icon

Overview

abstract

  • The medical records of 102 live-born children with a congenital diaphragmatic defect were reviewed to determine the frequency and nature of underlying chromosomal, genetic, and nongenetic patterns of malformation. Overall, 40 children (39%) had a major nonpulmonary malformation, and 14 of these children (14%) had a previously recognized pattern of malformation. A group of 18 children (18%) with cardiac anomalies had an increased mortality rate in comparison with those children without cardiac defects (72% vs 38%). The frequency and severity of nonpulmonary abnormalities in children with congenital diaphragmatic defects suggest that examination of affected children should include cardiac evaluation, a karyotype when the defect is one feature of a broader pattern of altered development, and a careful evaluation for minor anomalies, which may provide clues to an overall diagnosis.

publication date

  • February 1, 1990

Research

keywords

  • Abnormalities, Multiple
  • Diaphragmatic Eventration
  • Hernias, Diaphragmatic, Congenital

Identity

Scopus Document Identifier

  • 0025020955

Digital Object Identifier (DOI)

  • 10.1016/s0022-3476(05)82884-7

PubMed ID

  • 2299497

Additional Document Info

volume

  • 116

issue

  • 2