Science to practice: a new insight into nephrotoxicity after contrast medium administration.
Overview
abstract
Liu et al (1) have shown that iodinated contrast medium preferentially vasoconstricts the glomerular afferent arterioles by depleting endothelial nitric oxide bioavailability. This potentiates an exaggerated afferent arteriolar vasoconstricting response to angiotensin II and opens possibilities for new methods to prevent or treat nephrotoxicity after contrast medium administration.
