The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection. Academic Article uri icon

Overview

abstract

  • T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.

publication date

  • February 6, 2013

Research

keywords

  • Hepacivirus
  • Hepatitis C
  • Interleukin-7 Receptor alpha Subunit
  • Primate Diseases
  • T-Lymphocyte Subsets

Identity

PubMed Central ID

  • PMC3624391

Scopus Document Identifier

  • 84875785600

Digital Object Identifier (DOI)

  • 10.1371/journal.ppat.1000313

PubMed ID

  • 23388706

Additional Document Info

volume

  • 87

issue

  • 8