An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells. Academic Article uri icon

Overview

abstract

  • One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

publication date

  • January 1, 2013

Identity

PubMed Central ID

  • PMC3583917

Scopus Document Identifier

  • 79958189573

Digital Object Identifier (DOI)

  • 10.1002/path.2866

PubMed ID

  • 23482968

Additional Document Info

volume

  • 2

issue

  • 1