Mechanisms of disease: is mitochondrial function altered in heart failure? Review uri icon

Overview

abstract

  • The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.

publication date

  • January 1, 2013

Research

keywords

  • Energy Metabolism
  • Heart Failure
  • Mitochondria, Heart
  • Myocardium

Identity

PubMed Central ID

  • PMC3600884

Scopus Document Identifier

  • 84891706291

Digital Object Identifier (DOI)

  • 10.14797/mdcj-9-1-44

PubMed ID

  • 23519321

Additional Document Info

volume

  • 9

issue

  • 1