Myeloid-derived suppressor sells and the efficacy of CD8+ T-cell immunotherapy. Academic Article uri icon

Overview

abstract

  • Myeloid-derived suppressor cells (MDSCs) promote immune evasion, a key feature of oncogenesis. The restoration of immunosurveillance by immunomodulatory antibodies improves the survival of a subset of cancer patients. Preclinical studies suggest that the ablation of monocytic MDSCs may be a useful adjunct to available immunotherapeutic strategies against cancer.

publication date

  • February 1, 2013

Identity

PubMed Central ID

  • PMC3601158

Scopus Document Identifier

  • 84857815877

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1112824

PubMed ID

  • 23525353

Additional Document Info

volume

  • 2

issue

  • 2