T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques. Academic Article uri icon

Overview

abstract

  • APOBEC3 proteins mediate potent antiretroviral activity by hypermutating the retroviral genome during reverse transcription. To counteract APOBEC3 and gain a replicative advantage, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have evolved the Vif protein, which targets APOBEC3 proteins for proteasomal degradation. However, the proteasome plays a critical role in the generation of T cell peptide epitopes. Whether Vif-mediated destruction of APOBEC3 proteins leads to the generation and presentation of APOBEC3-derived T cell epitopes on the surfaces of lentivirus-infected cells remains unknown. Here, using peptides derived from multiple Vif-sensitive APOBEC3 proteins, we identified APOBEC3-specific T cell responses in both HIV-1-infected patients and SIV-infected rhesus macaques. These results raise the possibility that these T cell responses may be part of the larger antiretroviral immune response.

publication date

  • March 27, 2013

Research

keywords

  • CD8-Positive T-Lymphocytes
  • Cytidine Deaminase
  • Cytosine Deaminase
  • HIV Infections
  • HIV-1
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus

Identity

PubMed Central ID

  • PMC3648095

Scopus Document Identifier

  • 84878201045

Digital Object Identifier (DOI)

  • 10.1371/journal.ppat.1002221

PubMed ID

  • 23536679

Additional Document Info

volume

  • 87

issue

  • 11