A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors. Academic Article uri icon

Overview

abstract

  • 2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The (1) H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE = 97 ms provides higher detectability of 2HG than TE = 35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.

publication date

  • April 17, 2013

Research

keywords

  • Brain Neoplasms
  • Glioma
  • Glutarates
  • Magnetic Resonance Spectroscopy
  • Protons

Identity

PubMed Central ID

  • PMC3733061

Scopus Document Identifier

  • 84883791715

Digital Object Identifier (DOI)

  • 10.1002/nbm.2943

PubMed ID

  • 23592268

Additional Document Info

volume

  • 26

issue

  • 10