Discovering what makes STAT signaling TYK in T-ALL. uri icon

Overview

abstract

  • RNA interference screening establishes TYK2 dependence in T-cell acute lymphoblastic leukemia (T-ALL), leading to identification of TYK2-activating mutations and increased IL-10 receptor signaling in T-ALL cell lines. Cancer Discov; 3(5); 494-6. ©2013 AACR.

publication date

  • May 1, 2013

Research

keywords

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Proto-Oncogene Proteins c-bcl-2
  • STAT1 Transcription Factor
  • TYK2 Kinase

Identity

Scopus Document Identifier

  • 84877604884

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-13-0123

PubMed ID

  • 23658297

Additional Document Info

volume

  • 3

issue

  • 5