Weight loss after bariatric surgery in morbidly obese adolescents with MC4R mutations. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To determine the frequency of Melanocortin 4 Receptor (MC4R) mutations in morbidly obese adolescents undergoing bariatric surgery and compare weight loss outcomes in patients with and without mutations. DESIGN AND METHODS: In this prospective cohort study, 135 adolescent patients evaluated for bariatric surgery were screened for MC4R mutations; 56 had 12-month postoperative data available for analysis. RESULTS: MC4R mutations were detected in five of the 135 patients (3.7%); four underwent restrictive bariatric surgery. For the three patients with gastric banding, percent excess weight loss (%EWL) postoperatively was 36.0% at 5 years in one, 47% at 4 years in the second, and 85% at 1 year in the third. For the patient with gastric sleeve resection, %EWL of 96% was attained at 1 year postoperatively. The four MC4R cases had a higher, although nonsignificant, %EWL compared to 52 nonmatched controls at 12 months postoperatively (48.6% vs. 23.4%; P < 0.37). When matched by age, sex, and race to 14 controls, there was no significant difference in %EWL (P < 0.31), BMI change (P < 0.27), or absolute weight loss (P < 0.20). CONCLUSION: The frequency of MC4R mutations is similar to prior studies, with affected patients showing beneficial weight loss outcomes.

authors

  • Censani, Marisa A.
  • Conroy, Rushika
  • Deng, Liyong
  • Oberfield, Sharon E
  • McMahon, Donald J
  • Zitsman, Jeffrey L
  • Leibel, Rudy L
  • Chung, Wendy K
  • Fennoy, Ilene

publication date

  • October 15, 2013

Research

keywords

  • Bariatric Surgery
  • Obesity, Morbid
  • Receptor, Melanocortin, Type 4
  • Weight Loss

Identity

PubMed Central ID

  • PMC3880391

Scopus Document Identifier

  • 84892369340

Digital Object Identifier (DOI)

  • 10.1002/oby.20511

PubMed ID

  • 23740648

Additional Document Info

volume

  • 22

issue

  • 1