A berberine-loaded electrospun poly-(epsilon-caprolactone) nanofibrous membrane with hemostatic potential and antimicrobial property for wound dressing. Academic Article uri icon

Overview

abstract

  • In this study, a berberine-loaded electrospun poly-(epsilon-caprolactone) nanofibrous membrane (B-NFM) was formulated. The B-NFM was composed of uniform nanofibers with the average diameter of 190 +/- 53 nm. Whole blood assay revealed that the B-NFM had higher absorption capacity than gauze wound dressing (GWD) and non-drug-loaded nanofibrous membrane (NFM). Hemostatic studies showed that the B-NFM was more efficient at promoting blood clotting than GWD and NFM. B-NFM was also demonstrated to possess broad-spectrum antimicrobial activity. Biocompatibility studies indicated that B-NFM had good compatibility with skin fibroblast cells. These results suggested that the B-NFM can promote in vitro hemostasis to minimize wound bleeding, absorb biofluid to provide a favorable environment, inhibit on-site microbial agents to prevent wound infection, and support skin cell growth to facilitate wound healing. These data highly suggest a potential clinical use of B-NFM as wound dressing material.

publication date

  • July 1, 2013

Research

keywords

  • Anti-Bacterial Agents
  • Bandages
  • Berberine
  • Blood Loss, Surgical
  • Hemostatics
  • Membranes, Artificial
  • Polyesters

Identity

Scopus Document Identifier

  • 84880561648

Digital Object Identifier (DOI)

  • 10.1166/jbn.2013.1629

PubMed ID

  • 23909131

Additional Document Info

volume

  • 9

issue

  • 7