STAT signaling in the pathogenesis and treatment of myeloid malignancies. Review uri icon

Overview

abstract

  • STAT transcription factors play a critical role in mediating the effects of cytokines on myeloid cells. As STAT target genes control key processes such as survival, proliferation and self-renewal, it is not surprising that constitutive activation of STATs, particularly STAT3 and STAT5, are common events in many myeloid tumors. STATs are activated both by mutant tyrosine kinases as well as other pathogenic events, and continued activation of STATs is common in the setting of resistance to kinase inhibitors. Thus, the targeting of STATs, alone or in combination with other drugs, will likely have increasing importance for cancer therapy.

publication date

  • April 1, 2012

Identity

PubMed Central ID

  • PMC3670294

Scopus Document Identifier

  • 79957604461

Digital Object Identifier (DOI)

  • 10.1182/blood-2010-04-280123

PubMed ID

  • 24058751

Additional Document Info

volume

  • 1

issue

  • 2