Factors associated with response, survival, and limb salvage in patients undergoing isolated limb infusion. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Isolated limb infusion (ILI) is a percutaneous method of delivering regional chemotherapy to patients with recurrent tumors of the extremity. This study determines predictors of response, survival, and limb salvage. METHODS: Single institution data from a prospective clinical trial and subsequent ILI experience were reviewed. Limb tumor burden was assessed in melanoma patients with "high" (≥10 lesions or one lesion >3 cm) or "low" burden (<10 lesions and no lesion >3 cm). Response was assessed at 3 months from ILI. RESULTS: Between 1999 and 2011, 62 patients underwent ILI (58 melanoma, 2 Merkel cell carcinoma (MCC), 2 soft tissue sarcoma (STS)). Low tumor burden patients had more complete responses (CR) (11/23, 48%) than high tumor burden (3/32, 9%, P < 0.001); they had higher 5-year survival (69% vs. 29%, P = .007). Five-year survival rates based on response: 91% CR, 53% partial response (PR), 25% less than PR (P = 0.042, CR vs. PR). 7 patients (11%) underwent amputation due to disease progression; 3 had prior CR or PR. CONCLUSIONS: Low tumor burden is a significant predictor of response in melanoma patients. Response to ILI is a significant predictor of survival. Progression of limb disease requiring amputation is not associated with any factors.

publication date

  • December 7, 2013

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Carcinoma, Merkel Cell
  • Chemotherapy, Cancer, Regional Perfusion
  • Extremities
  • Melanoma
  • Sarcoma
  • Skin Neoplasms

Identity

Scopus Document Identifier

  • 84897026998

Digital Object Identifier (DOI)

  • 10.1002/jso.23519

PubMed ID

  • 24318953

Additional Document Info

volume

  • 109

issue

  • 5