Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. Academic Article uri icon

Overview

abstract

  • The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 on antimicrobial defense against infection, has yet to be reported but is important to define since SIRT1 inhibitors are being investigated as therapeutic agents in the treatment of cancer, Huntington's disease, and autoimmune diseases. Given the therapeutic potential of SIRT1 suppression, we sought to characterize the role of SIRT1 in host defense. Utilizing both pharmacologic methods and a genetic knockout, we demonstrate that SIRT1 expression has little influence on macrophage and neutrophil antimicrobial functions. Myeloid SIRT1 expression does not change mortality in gram-negative toxin-induced shock or gram-positive bacteremia, suggesting that therapeutic suppression of SIRT1 may be done safely without suppression of myeloid cell-specific immune responses to severe bacterial infections.

publication date

  • December 26, 2013

Research

keywords

  • Endotoxemia
  • Gene Expression Regulation
  • Gram-Positive Bacterial Infections
  • Myeloid Cells
  • Sirtuin 1

Identity

PubMed Central ID

  • PMC3873454

Scopus Document Identifier

  • 84891327061

Digital Object Identifier (DOI)

  • 10.1073/pnas.1934713100

PubMed ID

  • 24386389

Additional Document Info

volume

  • 8

issue

  • 12