Bortezomib therapy for nephrotic syndrome due to idiopathic membranous nephropathy. uri icon

Overview

abstract

  • Idiopathic membranous nephropathy is a common cause of nephrotic syndrome in adults. The nephrotic syndrome due to idiopathic membranous nephropathy is often resistant to glucocorticosteroids and requires an alkylating agent such as chlorambucil or cyclophosphamide to induce remission. Recent studies illustrate that antibodies against the autoantigen M-type phospholipase A2 receptor contribute to a vast majority but not all cases of idiopathic membranous nephropathy. Herein, we report a patient with nephrotic syndrome due to membranous nephropathy that was resistant to 6 months of therapy with ramipril and high-dose glucocorticosteroids but responded to a single cycle of bortezomib infusion.

publication date

  • January 16, 2014

Research

keywords

  • Boronic Acids
  • Glomerulonephritis, Membranous
  • Nephrotic Syndrome
  • Proteasome Inhibitors
  • Pyrazines

Identity

PubMed Central ID

  • PMC3966568

Scopus Document Identifier

  • 84896913221

Digital Object Identifier (DOI)

  • 10.2215/CJN.04160413

PubMed ID

  • 24430762

Additional Document Info

volume

  • 27

issue

  • 1