Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Review uri icon

Overview

abstract

  • We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.

publication date

  • February 1, 2014

Research

keywords

  • Epigenomics
  • Glioblastoma
  • Neoplasms, Nerve Tissue

Identity

PubMed Central ID

  • PMC4003223

Scopus Document Identifier

  • 84894573670

Digital Object Identifier (DOI)

  • 10.1002/stem.1554

PubMed ID

  • 24457416

Additional Document Info

volume

  • 14

issue

  • 2