Antibodies to sulfated glucuronic acid containing glycosphingolipids in neuropathy associated with anti-MAG antibodies and in normal subjects. Academic Article uri icon

Overview

abstract

  • Serum of patients with neuropathy and IgM monoclonal antibodies (M-proteins) that bind to the myelin-associated glycoprotein (MAG) were tested for binding to the major cross-reactive sulfated glucuronic acid containing glycosphingolipid, sulfated glucuronic acid paragloboside (SGPG). IgM binding to the glycolipid was detectable at serum dilutions of 1:10,000 and reactivity was greatest at 4 degrees C. Low titers of IgM binding to the glycolipid were also detected in sera from normal subjects and from patients with neurologic or rheumatologic diseases without serum M-proteins. Binding activity was present in 25% of the sera tested, and titers ranged between 1:25 and 1:400. One patient with peripheral neuropathy, however, had a measurable titer of 1:12,800 in the absence of monoclonal gammopathy. The study indicates that cold reacting anti-SGPG IgM antibodies are frequent constituents of the normal human antibody repertoire, and that monoclonal or polyclonal expansion of B cells that secrete these antibodies, is associated with peripheral neuropathy.

publication date

  • January 1, 1988

Research

keywords

  • Antibodies, Monoclonal
  • Autoantibodies
  • Autoimmune Diseases
  • Globosides
  • Glycosphingolipids
  • Hypergammaglobulinemia
  • Monoclonal Gammopathy of Undetermined Significance
  • Myelin Proteins
  • Peripheral Nervous System Diseases
  • Rheumatic Diseases

Identity

Scopus Document Identifier

  • 0023815816

Digital Object Identifier (DOI)

  • 10.1016/0165-5728(88)90019-7

PubMed ID

  • 2447123

Additional Document Info

volume

  • 17

issue

  • 2