Interferon-stimulated genes: a complex web of host defenses. Review uri icon

Overview

abstract

  • Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. In this review, we begin by introducing interferon (IFN) and the JAK-STAT signaling pathway to highlight features that impact ISG production. Next, we describe ways in which ISGs both enhance innate pathogen-sensing capabilities and negatively regulate signaling through the JAK-STAT pathway. Several ISGs that directly inhibit virus infection are described with an emphasis on those that impact early and late stages of the virus life cycle. Finally, we describe ongoing efforts to identify and characterize antiviral ISGs, and we provide a forward-looking perspective on the ISG landscape.

publication date

  • February 6, 2014

Research

keywords

  • Gene Expression Regulation
  • Immunity
  • Interferons

Identity

PubMed Central ID

  • PMC4313732

Scopus Document Identifier

  • 84896987305

Digital Object Identifier (DOI)

  • 10.1155/2010/470468

PubMed ID

  • 24555472

Additional Document Info

volume

  • 32