24- and 36-week outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS). Academic Article uri icon

Overview

abstract

  • OBJECTIVE: We report active treatment group differences on response and remission rates and changes in anxiety severity at weeks 24 and 36 for the Child/Adolescent Anxiety Multimodal Study (CAMS). METHOD: CAMS youth (N = 488; 74% ≤ 12 years of age) with DSM-IV separation, generalized, or social anxiety disorder were randomized to 12 weeks of cognitive-behavioral therapy (CBT), sertraline (SRT), CBT+SRT (COMB), or medication management/pill placebo (PBO). Responders attended 6 monthly booster sessions in their assigned treatment arm; youth in COMB and SRT continued on their medication throughout this period. Efficacy of COMB, SRT, and CBT (n = 412) was assessed at 24 and 36 weeks postrandomization. Youth randomized to PBO (n = 76) were offered active CAMS treatment if nonresponsive at week 12 or over follow-up and were not included here. Independent evaluators blind to study condition assessed anxiety severity, functioning, and treatment response. Concomitant treatments were allowed but monitored over follow-up. RESULTS: The majority (>80%) of acute responders maintained positive response at both weeks 24 and 36. Consistent with acute outcomes, COMB maintained advantage over CBT and SRT, which did not differ, on dimensional outcomes; the 3 treatments did not differ on most categorical outcomes over follow-up. Compared to COMB and CBT, youth in SRT obtained more concomitant psychosocial treatments, whereas those in SRT and CBT obtained more concomitant combined (medication plus psychosocial) treatment. CONCLUSIONS: COMB maintained advantage over CBT and SRT on some measures over follow-up, whereas the 2 monotherapies remained indistinguishable. The observed convergence of COMB and monotherapy may be related to greater use of concomitant treatment during follow-up among youth receiving the monotherapies, although other explanations are possible. Although outcomes were variable, most CAMS-treated youth experienced sustained treatment benefit. Clinical trial registration information-Child and Adolescent Anxiety Disorders (CAMS); URL: http://clinicaltrials.gov. Unique identifier: NCT00052078.

authors

  • Piacentini, John
  • Bennett, Shannon M.
  • Compton, Scott N
  • Kendall, Phillip C
  • Birmaher, Boris
  • Albano, Anne Marie
  • March, John
  • Sherrill, Joel
  • Sakolsky, Dara
  • Ginsburg, Golda
  • Rynn, Moira
  • Bergman, R Lindsey
  • Gosch, Elizabeth
  • Waslick, Bruce
  • Iyengar, Satish
  • McCracken, James
  • Walkup, John

publication date

  • November 28, 2013

Research

keywords

  • Anxiety Disorders
  • Cognitive Behavioral Therapy
  • Selective Serotonin Reuptake Inhibitors
  • Sertraline

Identity

PubMed Central ID

  • PMC3982864

Scopus Document Identifier

  • 84894587187

Digital Object Identifier (DOI)

  • 10.1016/j.jaac.2013.11.010

PubMed ID

  • 24565357

Additional Document Info

volume

  • 53

issue

  • 3