Mucoepidermoid carcinoma does not harbor transcriptionally active high risk human papillomavirus even in the absence of the MAML2 translocation. Academic Article uri icon

Overview

abstract

  • High risk human papillomavirus (HPV) is firmly established as an important cause of oropharyngeal carcinoma. Recent studies have also implicated HPV as a cause of mucoepidermoid carcinoma (MEC)-a tumor of salivary gland origin that frequently harbors MAML2 translocations. The purpose of this study was to determine the prevalence of transcriptionally active HPV in a large group of MECs and to determine whether HPV infection and the MAML2 translocation are mutually exclusive events. Break-apart fluorescence in situ hybridization for MAML2 was performed on a tissue microarray containing 92 MECs. HPV testing was performed using RNA in situ hybridization targeting high risk HPV mRNA E6/E7 transcripts. Of the 71 MECs that could be evaluated by FISH, 57 (80 %) harbored the MAML2 rearrangement. HPV was not detected in any of the 57 MECs that contained a MAML2 rearrangement, in any of the 14 MECs that did not contain the rearrangement, or in any of the 21 MECs where MAML2 status was unknown. High risk HPV does not appear to play any significant role in the development of MEC. It neither complements nor replaces MAML2 translocation in the tumorigenesis of MEC.

publication date

  • April 5, 2014

Research

keywords

  • Carcinoma, Mucoepidermoid
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Papillomavirus Infections
  • Salivary Gland Neoplasms
  • Transcription Factors

Identity

PubMed Central ID

  • PMC4126915

Scopus Document Identifier

  • 84905752402

Digital Object Identifier (DOI)

  • 10.1097/PAS.0b013e318220e59d

PubMed ID

  • 24706055

Additional Document Info

volume

  • 8

issue

  • 3