Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks. Review uri icon

Overview

abstract

  • MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.

publication date

  • April 12, 2014

Research

keywords

  • Gene Regulatory Networks
  • MicroRNAs
  • Mutation
  • Neoplasms
  • Tumor Suppressor Protein p53

Identity

PubMed Central ID

  • PMC6314029

Scopus Document Identifier

  • 84905098153

Digital Object Identifier (DOI)

  • 10.1038/onc.2014.46

PubMed ID

  • 24726728

Additional Document Info

volume

  • 588

issue

  • 16