Electrophysiologic study of experimental demyelination induced by serum of patients with IgM M proteins and neuropathy. Academic Article uri icon

Overview

abstract

  • We induced progressive conduction block in feline sciatic nerve by endoneurial injection of serum from 2 patients with demyelinating neuropathy and an anti-myelin-associated glycoprotein (MAG) IgM M protein. The block was longlasting (up to 4 days) and affected about half the motor nerve fibers. Control serum from patients with an IgM M protein that did not react with MAG produced a transient block (less than 48 hours) that affected an average of 25% of motor fibers. Nerves with sustained block showed widespread demyelination of many nerve fibers, exceeding controls. The findings support the view that chronic demyelinating neuropathy in these patients is caused by the anti-MAG M protein.

publication date

  • December 1, 1989

Research

keywords

  • Blood Proteins
  • Demyelinating Diseases
  • Immunoglobulin M
  • Immunoglobulins
  • Myelin Sheath

Identity

Scopus Document Identifier

  • 0024836627

Digital Object Identifier (DOI)

  • 10.1212/wnl.39.12.1581

PubMed ID

  • 2479887

Additional Document Info

volume

  • 39

issue

  • 12