Implications of Look AHEAD for clinical trials and clinical practice. Academic Article uri icon

Overview

abstract

  • Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.

publication date

  • June 22, 2014

Research

keywords

  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Obesity
  • Research Design
  • Risk Reduction Behavior
  • Weight Loss

Identity

PubMed Central ID

  • PMC4227940

Scopus Document Identifier

  • 84920381368

Digital Object Identifier (DOI)

  • 10.1111/dom.12318

PubMed ID

  • 24853636

Additional Document Info

volume

  • 16

issue

  • 12