Clonidine challenge of cortisol secretion in dementia and geriatric depression. Academic Article uri icon

Overview

abstract

  • The effect of oral clonidine challenge on cortisol secretion was evaluated in seven patients with primary degenerative dementia and in seven patients with major depression. Postclonidine cortisol levels were decreased in all depressed patients and in demented patients with hypercortisolemia at baseline. Demented patients with normal cortisol levels at baseline developed increased post-clonidine cortisol levels. These preliminary findings suggest differences in noradrenergic regulation of cortisol secretion among patients with primary degenerative dementia.

publication date

  • January 1, 1989

Research

keywords

  • Clonidine
  • Dementia
  • Depressive Disorder
  • Hydrocortisone

Identity

Scopus Document Identifier

  • 0024732679

Digital Object Identifier (DOI)

  • 10.1017/s1041610289000177

PubMed ID

  • 2491143

Additional Document Info

volume

  • 1

issue

  • 2