Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Invasive micropapillary carcinoma (IMPC) is a variant of breast carcinoma with a higher propensity for lymph node metastases compared with invasive ductal carcinoma (IDC). METHODS: Retrospective analysis of 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology and End RESULTS database comparing disease-specific survival (DSS) and overall survival (OS) between IMPC and IDC. RESULTS: A higher percentage of IMPC cases (52.0%) had nodal metastases compared with IDC cases (34.6%). The 5-year DSS and OS for IMPC was 91.8% and 82.9%, respectively compared with 88.6% and 80.5% for IDC, respectively. For both IMPC and IDC, oestrogen-receptor positivity was associated with better survival, while having four or more positive lymph nodes or larger tumour size correlated with worse survival. Radiotherapy provided a survival benefit for both histological types. CONCLUSIONS: Despite IMPC's higher propensity for lymph node metastasis, IMPC has DSS and OS that compare favourably with IDC.

publication date

  • June 12, 2014

Research

keywords

  • Breast Neoplasms
  • Carcinoma, Ductal, Breast
  • Carcinoma, Papillary

Identity

PubMed Central ID

  • PMC4119976

Scopus Document Identifier

  • 84905218837

Digital Object Identifier (DOI)

  • 10.1038/bjc.2014.301

PubMed ID

  • 24921921

Additional Document Info

volume

  • 111

issue

  • 3