Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression. Academic Article uri icon

Overview

abstract

  • Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These include changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.

publication date

  • March 1, 1989

Research

keywords

  • Cell Transformation, Neoplastic
  • Cell Transformation, Viral
  • Genes, ras
  • Kidney Neoplasms
  • Kidney Tubules, Proximal
  • Retroviridae

Identity

PubMed Central ID

  • PMC2189254

Scopus Document Identifier

  • 0024556427

Digital Object Identifier (DOI)

  • 10.1084/jem.169.3.953

PubMed ID

  • 2494294

Additional Document Info

volume

  • 169

issue

  • 3