Metabolic circuits in neural stem cells. Review uri icon

Overview

abstract

  • Metabolic activity indicative of cellular demand is emerging as a key player in cell fate decision. Numerous studies have demonstrated that diverse metabolic pathways have a critical role in the control of the proliferation, differentiation and quiescence of stem cells. The identification of neural stem/progenitor cells (NSPCs) and the characterization of their development and fate decision process have provided insight into the regenerative potential of the adult brain. As a result, the potential of NSPCs in cell replacement therapies for neurological diseases is rapidly growing. The aim of this review is to discuss the recent findings on the crosstalk among key regulators of NSPC development and the metabolic regulation crucial for the function and cell fate decisions of NSPCs. Fundamental understanding of the metabolic circuits in NSPCs may help to provide novel approaches for reactivating neurogenesis to treat degenerative brain conditions and cognitive decline.

publication date

  • July 19, 2014

Research

keywords

  • Gene Expression Regulation
  • Neural Stem Cells

Identity

PubMed Central ID

  • PMC4394599

Scopus Document Identifier

  • 84922069609

Digital Object Identifier (DOI)

  • 10.1038/sj.mp.4002084

PubMed ID

  • 25037158

Additional Document Info

volume

  • 71

issue

  • 21