Setting the course for apoAII: a port in sight? Academic Article uri icon

Overview

abstract

  • ApoAII, the second most abundant protein of the human plasma HDLs, was discovered nearly 50 years ago. Over the subsequent years, nearly 2000 studies - epidemiological, cell-based, biochemical, mouse and human - have attempted to unravel its role in human lipid metabolism. On the basis of these studies, apoAII has been described as an activator and inhibitor of various plasma activities, and as both pro- and anti-atherogenic. Here, we summarize the studies of apoAII, use the preponderance of evidence to propose that the apoAII compass can be reset towards an antiatherogenic course, and suggest ways to stay the course.

publication date

  • October 1, 2013

Identity

PubMed Central ID

  • PMC4108335

Scopus Document Identifier

  • 84884545513

Digital Object Identifier (DOI)

  • 10.2217/clp.13.59

PubMed ID

  • 25067958

Additional Document Info

volume

  • 8

issue

  • 5