Strategies for targeting the androgen receptor axis in prostate cancer. Review uri icon

Overview

abstract

  • Androgen receptor (AR) signaling plays a critical role in prostate cancer cell proliferation, survival, and differentiation. Therapeutic strategies targeting the androgen receptor have been developed for the treatment of metastatic hormone-naïve prostate cancer; however, despite effective targeting recent studies have demonstrated that during progression to a castrate-resistant phenotype there is restoration of AR target gene expression. On the basis of this observation, second-generation therapeutics have been developed to target AR in the castrate-resistant setting resulting in a survival benefit. In this review we will discuss the mechanisms promoting AR signaling and the development of second-generation therapeutics targeting AR in castrate-resistant prostate cancer.

publication date

  • August 10, 2014

Research

keywords

  • Androgen Receptor Antagonists
  • Prostatic Neoplasms, Castration-Resistant
  • Receptors, Androgen

Identity

Scopus Document Identifier

  • 84907806759

Digital Object Identifier (DOI)

  • 10.1016/j.drudis.2014.07.008

PubMed ID

  • 25107669

Additional Document Info

volume

  • 19

issue

  • 9