Immunophenotypic demonstration of two natural killer surface markers, H25 and H366, on fresh human leukemic cells. Academic Article uri icon

Overview

abstract

  • Using a modified alkaline-phosphatase/antialkaline-phosphatase method for phenotyping fresh human leukemias, we could demonstrate peripheral blood and bone marrow-derived blast cells to specifically react with two monoclonal antibodies (MoAbs), H25 and H366, previously shown to recognize natural killer cells, activated T lymphocytes and a proportion of normal hematopoietic precursor cells. MoAbs H25 and H366 were found to identify the majority of leukemic cells in patients presenting with T-ALL, LGL leukemia, pre-B-ALL, CML, and AML, respectively.

publication date

  • January 1, 1989

Research

keywords

  • Antibodies, Monoclonal
  • Antigens, Neoplasm
  • Antigens, Surface
  • Killer Cells, Natural
  • Leukemia

Identity

Scopus Document Identifier

  • 0024455953

Digital Object Identifier (DOI)

  • 10.1159/000205375

PubMed ID

  • 2511721

Additional Document Info

volume

  • 82

issue

  • 4