Blepharoptosis and HAART related mitochondrial myopathy.
Overview
abstract
PURPOSE: To report a case of blepharoptosis in a patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) with biopsy confirmed mitochondrial deletions consistent with HAART related myopathy. METHODS: A 51-year-old man with HIV demonstrated visually significant ptosis after being on HAART therapy for over 20 years. RESULTS: Muscle tissue biopsy following blepharoplasty was analyzed and found to have significant mitochondrial deletions. CONCLUSIONS: This patient represents a case of isolated ptosis consistent with acquired myopathy secondary to mitochondrial dysfunction without systemic manifestations otherwise seen in inherited mitochondrial disorders.
