Design and synthesis of a mitochondria-targeting carrier for small molecule drugs. Academic Article uri icon

Overview

abstract

  • A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.

publication date

  • December 28, 2014

Research

keywords

  • Drug Carriers
  • Drug Design
  • Mitochondria
  • Small Molecule Libraries

Identity

Scopus Document Identifier

  • 84911911028

Digital Object Identifier (DOI)

  • 10.1039/c4ob01981d

PubMed ID

  • 25378226

Additional Document Info

volume

  • 12

issue

  • 48